Endocrine Abstracts

Regulation of hepatic gluconeogenesis by insulin and glucagon is central to blood glucose homeostasis. It has been proposed that the members of AMP-activated protein kinase (AMPK)-related kinases, the salt inducible kinase (SIK) isoforms, may play a role as signalling mediator in the control of insulin- and glucagon-regulated hepatic gluconeogenesis. However, the exact regulation and contribution of SIKs in hepatic gluconeogenesis is largely elusive. Here we employed selective...

Background: Hyperprolactinemia is a biochemical finding with a broad differential diagnosis and is commonly measured during the work up for amenorrhea, galactorrhea, or hypogonadism. Diagnostic workup of hyperprolactinemia should be performed in a stepwise fashion to avoid incorrect diagnoses and/or unnecessary investigations. As mild hyperprolactinemia (i.e. <100 mg/l) can be physiologic or spurious, repeating the prolactin level is a crucial step in the initial workup. U...